JSTOR Daily

High-Resolution Mapping of the 11q13 Amplicon and Identification of a Gene, TAOS1, That Is Amplified and Overexpressed in Oral Cancer Cells

Amplification of chromosomal band 11q13 is a common event in human cancer. It has been reported in about 45% of head and neck carcinomas and in other cancers including esophageal, breast, liver, lung, ...
Nature

Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression

Although genome-wide association studies (GWAS) have identified the existence of numerous population-based cancer susceptibility loci, mechanistic insights remain limited, particularly for intergenic ...
Nature

MYEOV, a gene at 11q13, is coamplified with CCND1, but epigenetically inactivated in a subset of esophageal squamous cell carcinomas

Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan Tel. +81-3 ...
EurekAlert!

Amplified genome area mapped; New gene is overexpressed in oral cancer, say Pittsburgh researchers

PITTSBURGH, Aug. 1 – Investigators from the University of Pittsburgh have used a new technique to map a region of the genome – chromosomal band 11q13 – that is present in extra copies, or amplified, ...
GEN

Studies Link Asthma with Variations in IL6 Receptor Gene and Chromosome 11q13.5

Consortium says findings support hypothesis that genetic dysregulation of cytokine signaling increases asthma risk. The Australian Asthma Genetics Consortium (AAGC) claims the IL6R finding adds weight ...