Kickoff from NRG Stadium is set for 1 p.m. ET, and the Texans are 2.5-point favorites, according to the latest 49ers vs. Texans odds. The over/under for total points scored is 42. The Texans are -151 money line favorites (risk $151 to win $100),

San Francisco 49ers QB Mac Jones fired a strike to WR Kendrick Bourne, moving the chains with an 18-yard gain vs. the Texans.

With Brock Purdy continuing to miss time for the 49ers due to injury, Mac Jones has a great opportunity to maximize his earnings.

Jones is 3-1 as a fill-in starter for San Francisco, has had 142 receiving yards in each of his last two games.

San Francisco 49ers quarterback Brock Purdy has been ruled out for his team's Week 8 matchup against the Houston Texans amid his recovery from turf toe.

Jones hasn’t been announced as the starter Sunday night against the Atlanta Falcons (5:20 p.m., NBC) but was a full participant in practice despite knee and oblique issues. Incumbent Brock Purdy (turf toe) was limited and appears destined to miss his third straight game and fourth of the season.

San Francisco 49ers quarterback Mac Jones locates tight end George Kittle for a 17-yard sliding grab against the Houston Texans.