BIOENGINEER

Experimental AMPK activator traps esophageal cancer cells in S phase, priming them for chemotherapy

A laboratory study reports that the AMPK activator AICAR selectively arrests esophageal squamous cell carcinoma cells in S ...
News Medical

New redox-sensitive pathway reveals how cells activate AMPK in response to metabolic stress

AMP-activated protein kinase (AMPK) plays a central role in maintaining energy balance in cells, especially under energy stress. While upstream activation by the kinase LKB1 is well recognized, the ...
EurekAlert!

Cells sense energy stress via ROS

ROS-mediated PKCζ S-glutathionylation at Cys48 is essential for LKB1 cytoplasmic localization and AMPK activation upon energy stress. AMP-activated protein kinase (AMPK) plays a central role in ...
EurekAlert!

SOX9 overexpression ameliorates metabolic dysfunction-associated steatohepatitis through activation of the AMPK pathway

Our findings demonstrate that SOX9 overexpression alleviates hepatic lipid accumulation in MASH by activating the AMPK pathway. These results highlight SOX9 as a promising therapeutic target for ...
Business Wire

Cambrian Bio Presents Positive Human Translational Data for ATX-304, the First AMPK Network Activator, at the American Diabetes Association's 86th Scientific Sessions

Phase 1b data establish first clinical evidence of human translation of an AMPK Network Activator, with statistically significant improvements in liver fat, visceral adipose tissue, triglycerides, ...
Kaleido Scope

Time-restricted feeding promotes muscle function through purine cycle and AMPK signaling in Drosophila obesity models

Melkani’s lab study, titled "Time-restricted feeding promotes muscle function through purine cycle and AMPK signaling in Drosophila obesity models,” was recently published in Nature Communications.