Recently, pyrogen has been shown to be released from normal human blood leukocytes after stimulation by endotoxin or by phagocytosis of heat-killed bacteria. 4 When injected intravenously in rabbits, ...

THE pathogenesis of endotoxin fever has been much elucidated since the observation of the appearance in the serum of a fever-producing substance (endogenous pyrogen) after endotoxin 1. The transient ...

Fever is a condition where the internal body temperature becomes elevated, and it occurs when the temperature control center in the brain is reset. This thermostat is in the hypothalamus and is ...

SUBSTANCES capable of producing fever in normal recipients (the so-called endogenous pyrogens) appear in the serum of experimental animals during fever due to bacterial endotoxin, influenza virus and ...

ONE of the most striking effects of the administration of pituitary adrenocorticotrophic hormone (ACTH) to patients with febrile illnesses is the prompt defervescence that is frequently observed. The ...

Pyrogens and endotoxins are a diverse group of molecules – including components of microbes and environmental particles – that pose a contamination threat to pharmaceuticals, biotherapeutics and ...

In a new paper, researchers propose a mechanistic hypothesis that focuses on the potential impact infectious fever has on a particular subset of T cells, known as gamma/delta T cells. Recurring ...