Cancer cells are characterized by the presence of oncogene-induced DNA replication stress. A common consequence of replication stress is failure to complete DNA replication in S-phase, in which case, ...

Tousled-like kinases (TLKs) are nuclear serine-threonine kinases essential for genome maintenance and proper cell division in animals and plants. A major function of ...

Researchers at the University of Minnesota Medical School have developed a new method called PARTAGE that provides a clearer picture of how the genome is regulated and disrupted in diseases like ...

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

At the scale of individual cells, the human body is constantly in motion. Every second, millions of cells divide, particularly in tissues such as the bone marrow, intestine and skin; neurons and heart ...

Human genomic DNA is wrapped around core histone proteins to form nucleosomes, the fundamental units of chromatin. During interphase, the period between cell divisions, DNA is replicated and the ...

Human genomic DNA is wrapped around core histone proteins to form nucleosomes, the fundamental units of chromatin.

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...

Nearly every cell in your body contains the exact same DNA, from your skin cells to your brain cells. But how does a cell know how and when to turn into skin, muscle or brain? Imagine that the DNA in ...