Colman Domingo took over the JIMMY KIMMEL LIVE desk as guest host for an episode that ranged from tech commentary to street comedy. Domingo led the program through a monologue touching on Elon Musk's plan to use his Grok AI to produce what Musk describes as a historically accurate version of The Odyssey,

Every year television host and comedian Jimmy Kimmel takes a week off over the summer, and every year audiences are left wondering who is going to fill in his place. Guess no more: This year it’s West Philly’s own Colman Domingo.

Ike Barinholtz has connected Donald Trump to an explosive diarrhea outbreak on Jimmy Kimmel Live!. While stepping in for Kimmel, the guest host branded the situation “Trump diarrhea.” Barinholtz,

Colman Domingo closed out his guest hosting run on JIMMY KIMMEL LIVE with a monologue segment making the case for why the United States needs a Gen X president, a political argument he laid out for the studio audience on what he noted was his final night filling in for Jimmy Kimmel.

Jimmy Kimmel's replacement for this week addressed all of the backlash surrounding Christopher Nolan's The Odyssey, which was released over the weekend, during Jimmy Kimmel Live!

Kimmel signed off from "Jimmy Kimmel Live!” on June 18, telling fans he will be "taking the next two months off – this time voluntarily.”