New research linking heart rate variability to glymphatic clearance could lead to a simple new biomarker of dementia risk.

What enables the brain to go from intense concentration to a heightened state of alertness? A study carried out by neuroscientists at the University of Geneva (UNIGE), in collaboration with ETH Zurich ...

Mild exercise results in a feeling of mental clarity and enhances cognition and memory. A possible mechanism behind such effects is the activation of the arousal center in the brainstem, thereby ...

A new study has linked signs of heightened arousal and reactivity -- a core symptom of posttraumatic stress disorder (PTSD) -- to overactivity of the locus coeruleus (LC), a brain region that mediates ...

Tau aggregation begins not in the cortex, but in the brainstem. Does tangle deposition in the locus coeruleus, which often starts in a person’s 30s, presage Alzheimer’s disease? In the September 22 ...

The locus coeruleus is a region of the brain that is instrumental in coordinating our mental processing and is the primary source of noradrenaline in the brain, which acts to regulate arousal states ...

Optogenetic stimulation of the locus coeruleus noradrenergic neurons can increase wakefulness, and high-frequency stimulation decreases noradrenaline levels and produces loss of muscle tone similar to ...

Stress is implicated in diverse psychiatric disorders including substance abuse. The locus coeruleus–norepinephrine (LC–NE) system is a major stress response system that is also a point of ...

The locus coeruleus is emerging as a major new area of research interest, with many important functions such as regulating our attention and sleep. Anyone with insomnia knows the impatience and ...