Due to a loss of functionality in hematopoietic stem cells, immune defects occur during aging. Now, researchers have identified gene Per2, whose deletion leads to a stabilization of the number of ...

Researchers find that a key circadian clock controlling kinase, CK1D -- controlling the stability of PER2 -- has two forms, one that stabilizes PER2 and one that destabilizes it. A long-studied factor ...

CK1δ complexes assembling in the cytosol enter the nucleus, where PER2 hyperphosphorylation eventually disrupts the complex, causing PER2 to relocalize to the cytoplasm, allowing nuclear accumulation ...

No significant financial relationships to disclose. This is an ASCO Meeting Abstract from the 2008 ASCO Annual Meeting. This abstract does not include a full text component.