If your mouse pointer disappears on the second monitor on Windows 11/10, change these mouse settings and update the Mouse driver to resolve the issue.

Press the DPI switch button once and move the mouse. If the cursor speed changes, you’ve found the cause. Cycle through the available levels until it feels right. Go to Settings > Devices > Mouse.

If you don't like the default cursor in Windows 10 you can easily change it. You can also customize its color, size, and speed.