PsyPost on MSN

Scientists identify rare mutations in 36 genes that sharply raise the odds of OCD and tic disorders

A large-scale genetic analysis has identified 36 genes carrying rare mutations that substantially increase the likelihood of developing obsessive-compulsive disorder, chronic tic disorders, or both.
Morning Overview on MSN

A rare mutation may explain why some people with a high genetic Alzheimer’s risk stay sharp into their 80s

A rare mutation in a gene called FN1 may help explain why some people with the strongest common genetic risk for Alzheimer’s ...
BIOENGINEER

Novel ALPL Splice-Site Mutation Identified as Cause of Severe Perinatal Hypophosphatasia

Whole exome sequencing of an aborted fetus from a consanguineous Iranian family identified a novel homozygous ALPL ...

Boy, 11, Undergoes Successful Treatment for Rare Gene Mutation. Later, He Made This Specific Request to the Hospital (Exclusive)

Peyton Stewart was diagnosed with a rare genetic mutation that caused an autoimmune deficiency ...
BIOENGINEER

How Seven Tiny Mutations Break a Metabolic Enzyme and Cause a Rare Brain and Heart Syndrome

New crystal structures and biochemical analyses reveal that seven disease-causing SHMT2 mutations sabotage the same ...
newswise

Large-scale study advances detection of DNA mutations across the human genome

ROCHESTER, Minn. — Researchers in a Mayo Clinic-led study have shown how to detect a broad range of DNA mutations in noncancerous human tissues and across the genome. The analysis, drawing on more ...
BioSpace

New FDA draft guidance doubles down on expediting approvals of personalized gene therapies

The FDA has outlined a process for allowing a single application to cover multiple variants of a gene therapy. At the same ...
Phys.org

New DNA sequencing methods detect rare mutations acquired as bodies grow and age

Somatic mutations, the DNA changes that occur as our bodies grow and age, not only hold an important key to cancer but are emerging as the seeds of a wide range of common, noncancerous diseases. The ...

The 'Blueprint of Life' Revealed by 180 Million Years of Evolution: Unlocking Human Gene Importance with the New GISMO Metric

This article explains the development and evaluation of GISMO and GISMO-mis, new constraint metrics that utilize mammalian ...

CAMP4 Therapeutics Receives Clinical Trial Application Approval for Phase 1/2 Clinical Trial of CMP-002 in Patients with SYNGAP1-Related Disorder in the European Union

Approval under the EU Clinical Trials Regulation builds on CAMP4’s recent clearances in the United Kingdom, Australia, and Argentina to initiate ...
Chosunbiz

Prime editing enters first in-body trial to fix Wilson disease mutations

Prime editing enters first in-body trial to fix Wilson disease mutations First in-body gene edit targets common ATP7B flaw in ...
Nature

A first for CRISPR: powerful prime editing alters DNA directly in the human body

Application of the high-precision technique is part of a clinical trial to treat a genetic disease that can cause liver and ...