The fictional hospital on "Grey's Anatomy" sees a lot of turnover, which makes a ton of sense when you consider that the series has been airing steadily since 2005. Even characters (and their actors) who weren't part of Shonda Rhimes' medical drama since ...

The explosion’s consequences can force Meredith to surrender her role as Grey’s Anatomy ’s most tragic character to another one in season 22. Grey’s Anatomy highlighted multiple times how dark Meredith’s story was, whether in the medical drama’s timeline or beforehand, in relation to her family or her life in Seattle.

Grey’s Anatomy Season 22 returns with explosive drama at Grey Sloan Memorial. New episodes filled with emotional twist and medical miracle will air Thursdays at 10 pm ET on ABC

Here are all the characters and cast members who aren’t leaving/contractually obligated to appear in Grey’s Anatomy in Season 22. However, showrunner Meg Marinis revealed in a The Hollywood Reporter interview that no one — except Meredith Grey and ...