The Texans face the 49ers in a virtual must-win game for their playoff hopes. We'll have updates and anlysis throughout the day from NRG Stadium.

When the San Francisco 49ers finally picked up a first down Sunday against the Houston Texans they were already down by 16 points and there was less than a minute left in the first half.

The San Francisco 49ers (5-2) visit the Houston Texans (2-4) Sunday in Week 8. Kickoff from NRG Stadium in Houston, Texas, is at 1 p.m. ET (FOX). Let's analyze BetMGM Sportsbook's NFL odds around the 49ers vs. Texans odds and make our expert NFL picks and predictions for the best bets.

Instead of having to settle for another field goal, C.J, Stroud and Xavier Hutchinson hooked up to put the 49ers in a deeper hole.

Houston Texans quarterback C.J. Stroud (7) is congratulated by teammates Aireontae Ersery (79) and Tytus Howard (71) after throwing a touchdown pass during the second half of an NFL football game against the San Francisco 49ers Sunday, Oct. 26, 2025, in Houston. Credit: AP/Eric Christian Smith

The Texans face the 49ers in a virtual must-win game for their playoff hopes. We'll have updates and anlysis throughout the day from NRG Stadium.

The Texans are without two of their top wide receivers, Nico Collins and Christian Kirk. Also out for Houston are offensive tackles Trent Brown (the cousin of 49ers rookie defensive tackle Alfred Collins) and Jarrett Kingston (2024 sixth-round pick by the 49ers), defensive end Darrell Taylor, and quarterback Graham Mertz.